Effect of cadmium treatment on hepatic flavin metabolism
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Effect of cadmium treatment on hepatic flavin metabolism
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| Creator |
Bandyopadhyay, Debashis
Chatterjee, Ajay K Datta, Asoke G |
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| Subject |
Cell Biology & Physiology
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| Description |
The effect of cadmium on levels of hepatic riboflavin, flavin mononucleotide ( FMN), flavin adenine dinucleotide
(FAD), as well as the activities of flavokinase and FMN-phosphatase were studied following injection of cadmium sulfate solution subcutaneously to male Sprague-Dawley rats at a dose of O. 44 mg/ kg body weight,every alternate day for 15 days. The body weights and wet weights of liver were found to increase significantly following cadmium treatment (P < 0.01 and P < 0.001, respectively). The levels of hepatic-free riboflavin and FAD increased, while the FMN level remained unaltered (P < O. 01, P < O. 001, and P > O. 05, respectively).A significant decrease in activities of hepatic flavokinase and FMN-phosphatase were observed both in in vivo and in vitro experiments, although the degree of inhibition was found to be more pronounced in case of
flavokinase than FMN-phosphatase (P < 0.001 and P < 0.05, respectively).
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| Date |
1993
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2315/1/JOURNAL_OF_NUTRITIONAL_BIOCHEMISTRY__V._4___(_9_)510%2D514;1993[27].pdf
Bandyopadhyay, Debashis and Chatterjee, Ajay K and Datta, Asoke G (1993) Effect of cadmium treatment on hepatic flavin metabolism. Journal of Nutritional Biochemistry, 4 (9). pp. 510-514. |
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| Relation |
http://www.eprints.iicb.res.in/2315/
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