Synergistic actions of melatonin in combination with anti-parkinsonian drugs in experimental model of Parkinson’s disease
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Synergistic actions of melatonin in combination with anti-parkinsonian drugs in experimental model of Parkinson’s disease
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| Creator |
Naskar, Amit
Mohanakumar, K P |
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| Subject |
Cell Biology & Physiology
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| Description |
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive
degeneration and loss of nigrostriatal dopaminergic neurons in the midbrain, A9
substantia nigra neurons leading to severe striatal dopamine (DA) depletion resulting in
tremor, rigidity and hypokinesia (Carlsson, 2002). PD is named after James Parkinson
who first described the disease as “Shaking Palsy” (Paralysis Agitans) in his classic
monograph “An essay on the Shaking Palsy” (Parkinson, 1817). This debilitating disorder
has no cure existing, and recent epidemiological studies suggest an increasing trend in
its incidents; predicting an alarming 2-fold increase in affected population by 2030 in
several countries (Dorsey et al., 2007).
Currently used drugs for PD provides symptomatic relief, and are based on increasing
the striatal levels of DA, or controlling the DA transmission. However, these drugs are
generally short acting, and with time develop serious side effects. There are cases when
the drugs need to be discontinued due to exacerbation of DA-mediated effects. At this
juncture, there is a great need of alternative therapies, or designs that would effectively
reduce the dose of drugs that causes ‘on-off’ effects, dyskinesias, other undesirable
motor effects, non-motor complications, and slower the progression of the disease.
One of such effective therapy is using a peripheral aromatic amino acid decarboxylase
inhibitor, carbidopa along with L-3,4-dihydroxyphenylalanine (L-DOPA). The present
study mainly addressed such alternative approaches so as to find better therapeutic
agents that may synergize with the existing PD drugs.
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| Date |
2015
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2328/1/Amit_Naskar_Thesis.pdf
Naskar, Amit and Mohanakumar, K P (2015) Synergistic actions of melatonin in combination with anti-parkinsonian drugs in experimental model of Parkinson’s disease. PhD thesis, University of Calcutta. |
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| Relation |
http://www.eprints.iicb.res.in/2328/
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