Design, Synthesis And Evaluation of Anti- Inflammatory Activity of Gallic Acid Derivatives
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Design, Synthesis And Evaluation of Anti- Inflammatory Activity of Gallic Acid Derivatives
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| Creator |
Sarkar, Souvik
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| Subject |
Infectious Diseases and Immunology
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| Description |
Inflammation is the immunological defence mechanism exerted by the host in which the body fights against injury or infection from bacteria, viruses and other pathogens. The etiological features of inflammation as described in Latin are rubor (redness), calor (warmth), tumor (swelling) and dolor (pain) as described by Aurelius Cornelius, a Roman physician and medical writer who lived from about 30 B.C. to 45 A.D. The redness and swelling that occurs at the site of a wound is due to the broadening of blood vessels to create the passage for specialized immune cells and blood cells to enter the site of inflammation and combat the pathogens. Inflammation gradually gets wane following
the process and healing begins simultaneously for tissue regeneration. Inadequate or uncontrolled regulation of the inflammatory response mechanism can produce devastating effects and may generate different chronic diseases and severe tissue damage. After 1970s, non-steroidal anti-inflammatory drugs (NSAIDs) have been established to inhibit cyclooxygenase (COX), a class of physiological and pathophysiological inflammatory mediators which produces prostaglandins (PGs) [1]. Since then, the biosynthetic cascade of arachidonic acid (AA) has been the subject of intense research. COX and lipoxygenase (LOX) play a vital role in inflammation by controlling the intensity and duration of pain, as well as the occurrence of fever, swelling and heat of an affected area.Although steroidal anti-inflammatory drugs (SAIDs) and NSAIDs are currently used to treat acute inflammation, these drugs have severe genomic and nongenomic toxicities. These drugs are already
known for their gastrointestinal, renal and cardiovascular side effects. Recently, Vioxx and Celebrex, two effective drugs used to treat arthritis, were withdrawn for their cardiovascular toxicity. These cases provide examples of the unknown side effects produced by synthetic drugs, and suggest that an evaluation of the long-term effects of drugs may be required.
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| Date |
2015
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2380/1/Thesis_Souvik_Sarkar_;2015.pdf
Sarkar, Souvik (2015) Design, Synthesis And Evaluation of Anti- Inflammatory Activity of Gallic Acid Derivatives. PhD thesis, CU . |
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| Relation |
http://www.eprints.iicb.res.in/2380/
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