Novel Hexapeptide Interacts with Tubulin and Microtubules, Inhibits Aβ Fibrillation, and Shows Significant Neuroprotection
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Novel Hexapeptide Interacts with Tubulin and Microtubules, Inhibits Aβ Fibrillation, and Shows Significant Neuroprotection
|
|
| Creator |
Biswas, Atanu
Kurkute, Prashant Saleem, Suraiya Jana, Batakrishna Mohapatra, Saswat Mondal, Prasenjit Adak, Anindyasundar Ghosh, Subhajit Saha, Abhijit Bhunia, Debmalya Biswas, Subhash Chandra Ghosh, Surajit |
|
| Subject |
Cell Biology & Physiology
Chemistry |
|
| Description |
Herein, we report a novel hexapeptide, derived from activity
dependent neuroprotective protein (ADNP),that spontaneously selfassembles to form antiparallel β-sheet structure and produces nanovesicles under physiological conditions. This peptide not only strongly binds with β-tubulin in the taxol binding site but also binds with the microtubule lattice in
vitro as well as in intracellular microtubule networks. Interestingly, it shows inhibition of amyloid fibril formation upon co-incubation with Aβ peptide following an interesting mechanistic pathway and excellent neuroprotection in PC12 cells treated with anti-nerve growth factor (NGF). The potential of this hexapeptide opens up a new paradigm in design and development of novel
therapeutics for AD.
|
|
| Date |
2015
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/2381/1/ACS_CHEMICAL_NEUROSCIENCE__Vol.__6___(__8_)1309%2D1316;2015.pdf
Biswas, Atanu and Kurkute, Prashant and Saleem, Suraiya and Jana, Batakrishna and Mohapatra, Saswat and Mondal, Prasenjit and Adak, Anindyasundar and Ghosh, Subhajit and Saha, Abhijit and Bhunia, Debmalya and Biswas, Subhash Chandra and Ghosh, Surajit (2015) Novel Hexapeptide Interacts with Tubulin and Microtubules, Inhibits Aβ Fibrillation, and Shows Significant Neuroprotection. ACS Chemical Neuroscience, 6 (8). pp. 1309-1316. |
|
| Relation |
http://dx.doi.org/10.1021/acschemneuro.5b00149
http://www.eprints.iicb.res.in/2381/ |
|