Pulmonary Delivery of Voriconazole Loaded Nanoparticles Providing a Prolonged Drug Level in Lungs: A Promise for Treating Fungal Infection
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Pulmonary Delivery of Voriconazole Loaded Nanoparticles Providing a Prolonged Drug Level in Lungs: A Promise for Treating Fungal Infection
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| Creator |
Das, Pranab Jyoti
Paul, Paramita Mukherjee , Biswajit Mazumder, Bhaskar Mondal, Laboni Baishya, Rinku Chatterjee Debnath, Mita Dey, Kumar Saurav |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Current therapies are insufficient to prevent recurrent fungal infection especially in the lower part of the
lung. A careful and systematic understanding of the properties of nanoparticles plays a significant role in the design,development, optimization, and in vivo performances of the nanoparticles. In the present study, PLGA nanoparticles containing the antifungal drug voriconazole was prepared and two best formulations were selected for further characterization and in vivo studies. The nanoparticles and the free drug were radiolabeled with technetium-99m with 90% labelling efficiency, and the radiolabeled particles were administered to investigate the effect on their blood clearance, biodistribution, and
in vivo gamma imaging. In vivo deposition of the drug in the lobes of the lung was studied by LC−MS/MS study. The particles were found to be spherical and had an average hydrodynamic diameter of 300 nm with a smooth surface. The radiolabeled particles and the free drug were found to accumulate in various major organs. Drug accumulation was more pronounced in the lung in the case of administration of the nanoparticles than that of the free drug. The free drug was found to be excreted more rapidly than the nanoparticle containing drug following the inhalation route as assessed by gamma scintigraphy study. Thus, the
study reveals that pulmonary administration of nanoparticles containing voriconazole could be a better therapeutic choice even as compared to the iv route of administration of the free drug and/or the drug loaded nanoparticles.
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| Date |
2015
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2383/1/MOLECULAR_PHARMACEUTICS__Vol.__12___(__8)_Special_Issue__SI___2651%2D2664;2015.pdf
Das, Pranab Jyoti and Paul, Paramita and Mukherjee , Biswajit and Mazumder, Bhaskar and Mondal, Laboni and Baishya, Rinku and Chatterjee Debnath, Mita and Dey, Kumar Saurav (2015) Pulmonary Delivery of Voriconazole Loaded Nanoparticles Providing a Prolonged Drug Level in Lungs: A Promise for Treating Fungal Infection. Molecular Pharmaceutics, 12 (8). pp. 2651-2664. |
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| Relation |
http://dx.doi.org/10.1021/acs.molpharmaceut.5b00064
http://www.eprints.iicb.res.in/2383/ |
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