Plant glycosides in a liposomal drug-delivery system
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Plant glycosides in a liposomal drug-delivery system
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| Creator |
Das, Nirmalendu
Bachhawat, Bimal K Mahato, Shashi B Basu, Mukul K |
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| Subject |
Drug Development/Diagnostics & Biotechnology
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| Description |
Plant glycosides were incorporated into the liposomal surface to study their sugar-specific uptake by various
tissues. Two steroid glycosides, namely floribundasaponin D, with rhamnose as terminal sugar, and gracillin, with glucose and rhamnose as end sugars, were selected for the purpose. '25I-human IgG encapsulated liposomes composed of egg lecithin (phosphatidylcholine), cholesterol, dicetyl phosphate (optional) and either floribundasaponin D or gracillin, when injected into the tail vein of rat, showed
significantly higher uptake in the rat liver than in appropriate controls. Whereas the uptake of
floribundasaponin D liposomes was observed to be non-specific, the increased uptake of the gracillin
liposomes, as judged from the inhibition studies with asppropriate sugars, was specific for glucose, although
the receptor was unable to distinguish between the a and /, anomers ('anomerically blind'). The liverperfusion
studies showed that the uptake of gracillin liposomes was mostly by non-parenchymal cells.
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| Publisher |
Portland Press
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| Date |
1987
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2396/1/Biochem._J._(1987)_247%2C_359%2D361.pdf
Das, Nirmalendu and Bachhawat, Bimal K and Mahato, Shashi B and Basu, Mukul K (1987) Plant glycosides in a liposomal drug-delivery system. Biochemical Journal, 247. pp. 359-361. ISSN 0264-6021 |
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| Relation |
http://www.eprints.iicb.res.in/2396/
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