Immunomodulatory effects of antileishmanial drugs
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Immunomodulatory effects of antileishmanial drugs
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| Creator |
Ghosh, Moumita
Roy, Koushik Roy, Syamal |
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| Subject |
Infectious Diseases and Immunology
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| Description |
The commonly used antileishmanial drugs are sodium antimony gluconate (SAG), amphotericin B,
miltefosineandparomomycin. Thereareanumberof reports that antileishmanial drugsshowimmunomodulatory
properties. Here,we attempt to understand howthe innatearmof theimmunesystemis modulated in response to
these antileishmanial drugs.
BALB/c peritoneal macrophages were treated with miltefosine, SAG, amphotericin B or paromomycin.
Themembrane fluidity of macrophages following drug treatmentwas studied in terms of fluorescence anisotropy.
The T cell-stimulating ability, production of cytokines and nitrogen and oxygen metabolite production in drugtreated
macrophages were also studied. The study was also carried out using peritoneal macrophages from drug-treated BALB/c mice.
The antileishmanial drugs altered macrophage membrane fluidity, except amphotericin B. The drugtreated
macrophages showed enhanced T cell-stimulating ability and generation of reactive oxygen species, nitrite, interleukin-12 and tumour necrosis factor-a Antileishmanial drugs can stimulate the innate arm of the immune system, which may have a significant
bearing on the cellular arm of the immune system.
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| Publisher |
Oxford University Press
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| Date |
2013
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2405/1/JOURNAL_OF_ANTIMICROBIAL_CHEMOTHERAPY__Volume__68____Issue__12____Pages__2834%2D2838.pdf
Ghosh, Moumita and Roy, Koushik and Roy, Syamal (2013) Immunomodulatory effects of antileishmanial drugs. Journal of Antimicrobial Chemotherapy, 68 (12). pp. 2834-2838. |
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| Relation |
http://dx.doi.org/10.1093/jac/dkt262
http://www.eprints.iicb.res.in/2405/ |
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