A transient reversal of miRNA-mediated repression controls macrophage activation
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
A transient reversal of miRNA-mediated repression
controls macrophage activation
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| Creator |
Mazumdar, Anup
Bose, Mainak Chakraborty, Abhijit Chakrabarti, Saikat Bhattacharyya, Suvendra Nath |
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| Subject |
Molecular & Human Genetics
Structural Biology & Bioinformatics |
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| Description |
In mammalian macrophages, the expression of a number of
cytokines is regulated by miRNAs. Upon macrophage activation, proinflammatory cytokine mRNAs are translated,
although the expression of miRNAs targeting these mRNAs
remains largely unaltered. We show that there is a transient
reversal of miRNA-mediated repression during the early phase of the inflammatory response in macrophages, which leads to the protection of cytokine mRNAs from miRNA-mediated repression. This derepression occurs through Ago2 phosphorylation, which results in its impaired binding to miRNAs and to the corresponding target mRNAs. Macrophages expressing a mutant, non-phosphorylatable AGO2—which remains bound to miRNAs during macrophage activation—have a weakened inflammatory response and fail to prevent parasite invasion. These findings highlight the relevance of the transient relief of miRNA repression for macrophage function
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| Publisher |
Nature Publishing Group
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| Date |
2013
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2417/1/EMBO_REPORTS__Volume__14____Issue__11____Pages__1008%2D1016%2D2013.pdf
Mazumdar, Anup and Bose, Mainak and Chakraborty, Abhijit and Chakrabarti, Saikat and Bhattacharyya, Suvendra Nath (2013) A transient reversal of miRNA-mediated repression controls macrophage activation. EMBO Reports, 14 (11). pp. 1008-1016. |
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| Relation |
http://dx.doi.org/10.1038/embor.2013.149
http://www.eprints.iicb.res.in/2417/ |
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