Synthesis and Cytotoxicity Studies of Novel Triazolo- Benzoxazepine as New Anticancer Agents
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Synthesis and Cytotoxicity Studies of Novel Triazolo-
Benzoxazepine as New Anticancer Agents
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| Creator |
Banerji, Biswadip
Pramanik, Sumit Kumar Sanphui, Priyankar Nikhar, Sameer Biswas, Subhas C |
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| Subject |
Cell Biology & Physiology
Chemistry |
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| Description |
Cancer continues to be one of the biggest threats to
the human civilization because there is no cure of it.
Small heterocyclic molecule with low molecular weight
and novel structural feature is therapeutically highly
demanding. These molecules have the capability to
disrupt signaling pathways leading to anticancer activities.
Therefore, the search for new anticancer agents
continues to draw attention to the research community.
In this study, a small triazolo-benzoxazepine scaffolds
was synthesized using a one-pot four-step synthetic methodology involving click reaction. Small libraries of 12 compounds were successfully synthesized and screened them against different cancer cell lines. Low micromolar anticancer activity was recorded using MTT assay, and further confirmation of cell death was obtained by phase contrast, fluorescent, and confocal images
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| Date |
2013
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2430/1/CHEMICAL_BIOLOGY_%26_DRUG_DESIGN__Vol._82_(_4_)__401%2D409;2013.pdf
Banerji, Biswadip and Pramanik, Sumit Kumar and Sanphui, Priyankar and Nikhar, Sameer and Biswas, Subhas C (2013) Synthesis and Cytotoxicity Studies of Novel Triazolo- Benzoxazepine as New Anticancer Agents. Chemical Biology & Drug design, 82 (4). pp. 401-409. |
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| Relation |
http://dx.doi.org/10.1111/cbdd.12164
http://www.eprints.iicb.res.in/2430/ |
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