Dual hit’ metabolic modulator LDCA selectively kills cancer cells by efficient competitive inhibition of LDH-A†
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Dual hit’ metabolic modulator LDCA selectively kills cancer cells by efficient competitive inhibition of LDH-A†
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| Creator |
Ghosh, Monisankar
Saha, Suchandrima Dutta, Samir Kumar |
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| Subject |
Drug Development/Diagnostics & Biotechnology
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| Description |
Herein, we synthesize and elucidate the potential of a novel ‘dual
hit’ molecule, LDCA, to constitutively block lactate dehydrogenase
isoform-A (LDH-A) to selectively subvert apoptosis and rigorously
attenuate breast tumor progression in amouse model, comprehensively
delineating the therapeutic prospectus of LDCA in the field of cancer
metabolics
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| Publisher |
Royal Society of Chemistry
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| Date |
2016
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2439/1/Chem._Commun.%2C_vol._52%2C_2401%2D%2D2404;2016%2C.pdf
Ghosh, Monisankar and Saha, Suchandrima and Dutta, Samir Kumar (2016) Dual hit’ metabolic modulator LDCA selectively kills cancer cells by efficient competitive inhibition of LDH-A†. Chemical Communications, 52. pp. 2401-2404. |
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| Relation |
http://dx.doi.org/10.1039/c5cc09903j
http://www.eprints.iicb.res.in/2439/ |
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