mRNA Targeting to Endoplasmic Reticulum Precedes Ago Protein Interaction and MicroRNA (miRNA)-mediated Translation Repression in Mammalian Cells
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
mRNA Targeting to Endoplasmic Reticulum Precedes Ago Protein Interaction and MicroRNA
(miRNA)-mediated Translation Repression in Mammalian Cells
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| Creator |
Barman, Bahnisikha
Bhattacharyya, Suvendra Nath |
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| Subject |
Molecular & Human Genetics
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| Description |
miRNA, Ago2, and target messages are enriched on ER in metazoan cells. Polysome association of newly formed mRNA
precedes Ago2 binding on ER membrane and its translation
repression. miRNA repression process is compartmentalized
in mammalian cells, and polysome association of
mRNA happens before the repression. This work provides a detailed understanding of the miRNA-mediated gene repression and mRNA compartmentalization in mammalian cells.
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| Publisher |
American Society for Biochemistry and Molecular Biology
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| Date |
2015
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2456/1/JOURNAL_OF_BIOLOGICAL_CHEMISTRY__Volume__290___(_41_)___24650%2D24656;2015.pdf
Barman, Bahnisikha and Bhattacharyya, Suvendra Nath (2015) mRNA Targeting to Endoplasmic Reticulum Precedes Ago Protein Interaction and MicroRNA (miRNA)-mediated Translation Repression in Mammalian Cells. The Journal of Biological Chemistry, 290 (41). pp. 24650-24656. |
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| Relation |
http://dx.doi.org/10.1074/jbc.C115.661868
http://www.eprints.iicb.res.in/2456/ |
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