Tricarbonyl 99mTc(I) and Re(I)–thiosemicarbazone complexes: synthesis, characterization and biological evaluation for targeting bacterial infection
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Tricarbonyl 99mTc(I) and Re(I)–thiosemicarbazone complexes: synthesis, characterization and biological evaluation for targeting bacterial infection
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| Creator |
Nayak, Dipak Kumar
Baishya, Rinku Natarajan, Ramalingam Sen, Tuhinadri Chatterjee Debnath, Mita |
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| Subject |
Infectious Diseases and Immunology
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| Description |
Methyl, ethyl and phenyl nitrofuryl thiosemicarbazone ligands (1, 2 and 3 respectively) were radiolabeled
with freshly prepared aqueous solution of a fac[99mTc(CO)3(H2O)3]+ precursor. The radiochemical yield was around 98% as determined by thin layer chromatography and HPLC. The complexes exhibited substantial stability. The corresponding Re(I) complexes were prepared from a Re(CO)5Br precursor to understand the coordination behavior of the ligands against a tricarbonyl rhenium(I) precursor. The rhenium(I) complexes were characterized by means of IR, NMR and mass spectroscopic studies as well as by X-ray
crystallography, and correlated with the technetium complexes by means of HPLC studies. Electrochemical
reduction of monomeric Re(CO)3-complexes of nitrofuryl ethyl thiosemicarbazone was also studied using cyclic voltammetry. Biodistribution studies of 99mTc(CO)3-labeled thiosemicarbazones in rats intramuscularly infected with S. aureus exhibited substantial in vivo stability of the complex and moderate accumulation at the site of focal infection
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| Publisher |
Royal Society of Chemistry
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| Date |
2015
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2519/1/dalton_trans_thiosemicabazone_(1).pdf
Nayak, Dipak Kumar and Baishya, Rinku and Natarajan, Ramalingam and Sen, Tuhinadri and Chatterjee Debnath, Mita (2015) Tricarbonyl 99mTc(I) and Re(I)–thiosemicarbazone complexes: synthesis, characterization and biological evaluation for targeting bacterial infection. Dalton Transactions, 44. pp. 16136-16148. |
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| Relation |
http://dx.doi.org/10.1039/c5dt02264a
http://www.eprints.iicb.res.in/2519/ |
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