Synthesis of S-thiomethyl MAG3, radiolabelling with technetium-99m and biological evaluation
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Synthesis of S-thiomethyl MAG3, radiolabelling with technetium-99m and biological evaluation
|
|
| Creator |
Sanyal, Kasturi
Chattopadhyay, Sankha Chatterjee Debnath, Mita |
|
| Subject |
Infectious Diseases and Immunology
|
|
| Description |
Protection of the thiolate function of the mercaptoacetyltriglycine (MAG3) by S-thiomethyl group allows automatic deprotection of the protecting group during technetium-99m radiolabelling by transchelation using stannous chloride dihydrate as reductant. Protection of the thiolate group with S-thiomethyl increases the stability of the ligand, desired complex of high
radiochemical purity could be prepared under relatively mild labelling condition (at room temperature) omitting the aeration step. The complex prepared from the S-thiomethyl protected MAG3 ligand were chromatographically (HPLC) and biologically compared with the corresponding complex prepared from the S-benzoylated MAG3 precursor. This result suggests that technetium-99m complex of MAG3 could be prepared from S-thiomethylated MAG3 precursor in comparatively higher purity under relatively milder labelling condition and this method of radiolabelling could be used for the development of less cumbrous single vial MAG3 kit
|
|
| Date |
2012
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/2520/1/J._Label_Compd._Radiopharm.pdf
Sanyal, Kasturi and Chattopadhyay, Sankha and Chatterjee Debnath, Mita (2012) Synthesis of S-thiomethyl MAG3, radiolabelling with technetium-99m and biological evaluation. Journal Labelled Compounds and Radiopharmaceutical, 55. pp. 377-382. |
|
| Relation |
http://dx.doi.org/10.1002/jlcr.2954
http://www.eprints.iicb.res.in/2520/ |
|