Genetic and epigenetic signature of matrix metalloproteinase and tissue inhibitor of metalloproteinases and their association with risk of gastric carcinoma
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Genetic and epigenetic signature of matrix
metalloproteinase and tissue inhibitor of
metalloproteinases and their association with risk of gastric carcinoma
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| Creator |
Kesh, Kousik Kumar
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| Subject |
Cancer Biology and Inflammatory Disorder Division
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| Description |
Cancer (medical term: malignant neoplasm) is a disease of uncontrolled cellular growth, invasion that sometimes spread to other locations in the body via lymph or
blood. Six potential alterations occur in cell physiology during cancer progression: (a) self support in growth signals (b) insensitivity to growth-inhibitory signals (c)
escape from apoptosis (d) infinite replication (e) sustained angiogenesis and (f) tissue invasion and metastasis (Hanahan and Weinberg 2011, 2000). Tumor cells
follow a multistep process namely: tumor cell detachment, local invasion, cell motility, angiogenesis, vessel invasion, survival in circulation, adhesion to
endothelial cells, extravasation and regrowth in different organs during metastasis (Hanahan and Weinberg 2000). Stomach cancer or gastric cancer is developed from
the lining of the stomach and found most often in people of older age. The disease affects men twice as often as women. Although the overall incidence rate of gastric
cancer is declining over the last several decades however, gastric cancer remains the forth most common type of cancer and is the second leading cause of cancerrelated
death worldwide (Jemal et al. 2011; Bertuccio et al. 2009). The steady decline in the incidence and mortality of stomach cancer in most developed countries is due to changes in nutrition pattern, improvement in food storage,
advanced treatment and control of H. pylori infection (Jarosz et al. 2011; Amiri, Janssen, and Kunst 2011; Zhu and Sonnenberg 2012; Katanoda and Yako-Suketomo 2009; Bertuccio et al. 2009). Early gastric cancer symptoms may be associated with indigestion or a burning sensation (heartburn), which most of the cases remain neglected in developing countries. However, about 2% referred for
endoscopy due to indigestion are diagnosed as gastric cancer. Unfortunately, in most of the cases, gastric cancer diagnose at late stage when the disease reaches in
an advanced stage (Maconi, Manes, and Porro 2008). Advanced or metastatic gastric cancer treatment achieved little progress with survival of less than 1 year (Wilke and Van Cutsem 2003).
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| Date |
2016
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2524/1/Koushik_K._Kesh_Thesis.pdf
Kesh, Kousik Kumar (2016) Genetic and epigenetic signature of matrix metalloproteinase and tissue inhibitor of metalloproteinases and their association with risk of gastric carcinoma. PhD thesis, J U. |
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| Relation |
http://www.eprints.iicb.res.in/2524/
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