A novel RING finger in the C-terminal domain of the coatomer protein α-COP.
IR@IMTECH: CSIR-Institute of Microbial Technology, Chandigarh
View Archive Info| Field | Value | |
| Title |
A novel RING finger in the C-terminal domain of the coatomer protein α-COP.
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| Creator |
Kaur, Gurmeet
Subramanian, Srikrishna |
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| Subject |
QR Microbiology
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| Description |
The C-terminal domain of α-COP, an essential subunit of the COPI coatomer complex, is composed of an all α-helical region and a small β-sheet domain. We show that this β-sheet domain is a Really Interesting New Gene (RING)-like treble clef zinc finger. The zinc-binding residues are substituted by other aminoacids in many homologs including the structurally-characterized proteins from Saccharomyces cerevisiae and Bos taurus. This RING-like domain is possibly related to those of other vesicle membrane-associated complexes, such as CORVET, HOPS and SEA, and likely mediates interactions with Dsl1p and assist in coat oligomerization.
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| Publisher |
BioMed Central
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| Date |
2015
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| Type |
Article
PeerReviewed |
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| Relation |
http://www.biologydirect.com//content/10/1/70
http://crdd.osdd.net/open/1734/ |
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| Identifier |
Kaur, Gurmeet and Subramanian, Srikrishna (2015) A novel RING finger in the C-terminal domain of the coatomer protein α-COP. Biology direct, 10 (1). p. 70. ISSN 1745-6150
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