Designing B-Cell Epitopes for Immunotherapy and Subunit Vaccines.
IR@IMTECH: CSIR-Institute of Microbial Technology, Chandigarh
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| Title |
Designing B-Cell Epitopes for Immunotherapy and Subunit Vaccines.
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| Creator |
Singh, Harinder
Gupta, Sudheer Gautam, Ankur Raghava, G.P.S. |
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| Subject |
QR Microbiology
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| Description |
Rationally designed subunit vaccines mainly consist of small peptides or B-cell epitopes, which can stimulate the body's immune response. Development of subunit vaccines is a very tedious and costly process. One of the imperative and crucial steps of vaccine development is the identification of highly competent B-cell epitopes as most of the proteins and fragments of proteins are immunologically irrelevant. With the advances in bioinformatics tools, it can be possible to precisely narrow down potential B-cell epitopes from the whole proteome of any pathogen. This chapter sheds light on prediction and designing of B-cell epitopes using two in silico tools LBtope and IgPred.
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| Publisher |
Springer
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| Date |
2015
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| Type |
Article
PeerReviewed |
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| Relation |
http://link.springer.com/protocol/10.1007%2F978-1-4939-2999-3_28
http://crdd.osdd.net/open/1751/ |
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| Identifier |
Singh, Harinder and Gupta, Sudheer and Gautam, Ankur and Raghava, G.P.S. (2015) Designing B-Cell Epitopes for Immunotherapy and Subunit Vaccines. Methods in molecular biology (Clifton, N.J.), 1348. pp. 327-40. ISSN 1940-6029
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