Adipose recruitment and activation of plasmacytoid dendritic cells fuel metaflammation
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Adipose recruitment and activation of plasmacytoid dendritic cells fuel metaflammation
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| Creator |
Ghosh, Amrit Raj
Bhattacharya, Roopkatha Bhattacharya, Shamik Nargis, Titli Rahaman, Oindrila Duttagupta, Pritam Raychaudhuri, Deblina Liu, Chinky Shiu Chen Roy, Shounak Ghosh, Parasar Khanna, Shashi Chaudhuri, Tamonas Tantia, Om Haak, Stefan Bandyopadhyay, Santu Mukhopadhyay, Satinath Chakrabarti, Partha Ganguly, Dipyaman |
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| Subject |
Cancer Biology and Inflammatory Disorder Division
Cell Biology & Physiology |
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| Description |
In obese individuals the visceral adipose tissue (VAT) becomes seat of chronic low grade inflammation (metaflammation). But the mechanistic link between increased adiposity and metaflammation remains largely unclear. We report here that in obese individuals
deregulation of a specific adipokine, chemerin, contributes to innate initiation of metaflammation, by recruiting circulating plasmacytoid dendritic cells (pDCs) into visceral adipose tissue via chemokine-like receptor 1 (CMKLR1). Adipose tissue-derived high
mobility group B1 (HMGB1) protein, activates toll-like receptor 9 (TLR9) in the adiposerecruited
pDCs by transporting extracellular DNA via receptor for advanced glycation endproducts (RAGE) and induces production of type I interferons. Type I interferons in
turn help in proinflammatory polarization of adipose-resident macrophages. Interferon signature gene expression in VAT correlates with both adipose tissue and systemic insulin resistance in obese individuals, represented by ADIPO-IR and HOMA2-IR respectively,
and defines two subgroups with different susceptibility to insulin resistance. Thus our study reveals a hitherto unknown pathway that drives adipose tissue inflammation and consequent insulin resistance in obesity.
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| Publisher |
American Diabetes Association
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| Date |
2016
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2542/1/db16%2D0331.full.pdf
Ghosh, Amrit Raj and Bhattacharya, Roopkatha and Bhattacharya, Shamik and Nargis, Titli and Rahaman, Oindrila and Duttagupta, Pritam and Raychaudhuri, Deblina and Liu, Chinky Shiu Chen and Roy, Shounak and Ghosh, Parasar and Khanna, Shashi and Chaudhuri, Tamonas and Tantia, Om and Haak, Stefan and Bandyopadhyay, Santu and Mukhopadhyay, Satinath and Chakrabarti, Partha and Ganguly, Dipyaman (2016) Adipose recruitment and activation of plasmacytoid dendritic cells fuel metaflammation. Diabetes. ISSN 0012-1797 (In Press) |
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| Relation |
http://dx.doi.org/10.2337/db16-0331
http://www.eprints.iicb.res.in/2542/ |
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