A New DNA Methyltransferase-Histone Deacetylase-Kinase Axis in Innate Immunity
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
A New DNA Methyltransferase-Histone Deacetylase-Kinase Axis in Innate Immunity
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| Creator |
Ghosh, Gourisankar
Sen, Malini |
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| Subject |
Cancer Biology and Inflammatory Disorder Division
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| Description |
Regulatory roles of protein and DNA modifications in gene expression during host defense have long been
appreciated. In a recent article published in Nature Immunology, Li et al. (2016) provide a unique glimpse of
yet another aspect of coordinated DNA methylation and protein acetylation in host response to pathogenic
stimuli. They elegantly demonstrate thatDNAmethylation and transcriptional activation at theHDAC9promoter
by DNMT3a, along with lysine deacetylation of TBK1 by HDAC9, are essential events during host defense
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| Publisher |
Elsevier
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| Date |
2016-08-18
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2553/1/Molecular_Cell_63%2C_August_18%2C_2016.pdf
Ghosh, Gourisankar and Sen, Malini (2016) A New DNA Methyltransferase-Histone Deacetylase-Kinase Axis in Innate Immunity. Molecular Cell, 63 (4). pp. 544-546. |
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| Relation |
http://dx.doi.org/10.1016/j.molcel.2016.08.007
http://www.eprints.iicb.res.in/2553/ |
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