Influence of Lipid Core Material on Physicochemical Characteristics of an Ursolic Acid-Loaded Nanostructured Lipid Carrier: An Attempt to Enhance Anticancer Activity
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Influence of Lipid Core Material on Physicochemical Characteristics of an Ursolic Acid-Loaded Nanostructured Lipid Carrier: An Attempt to Enhance Anticancer Activity
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| Creator |
Nahak, Prasant
Karmakar, Gourab Chettri, Priyam Roy, Biplab Guha, Pritam Besra, Shila Elizabeth Soren, Anjana Bykov, Alexey G Akentiev, Alexander V Noskov, Boris A Panda, Amiya Kumar |
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| Subject |
Cancer Biology and Inflammatory Disorder Division
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| Description |
The impact of saturation and unsaturation in the fatty acyl
hydrocarbon chain on the physicochemical properties of nanostructured lipid
carriers (NLCs) was investigated to develop novel delivery systems loaded with
an anticancer drug, ursolic acid (UA). Aqueous NLC dispersions were prepared
by a high-pressure homogenization−ultrasonication technique with Tween 80 as
a stabilizer. Mutual miscibility of the components at the air−water interface was
assessed by surface pressure−area measurements, where attractive interactions
were recorded between the lipid mixtures and UA, irrespective of the extent of
saturation or unsaturation in fatty acyl chains. NLCs were characterized by
combined dynamic light scattering, transmission electron microscopy (TEM),
atomic force microscopy (AFM), differential scanning calorimetry, drug
encapsulation efficiency, drug payload, in vitro drug release, and in vitro
cytotoxicity studies. The saturated lipid-based NLCs were larger than unsaturated
lipids. TEM and AFM images revealed the spherical and smooth surface
morphology of NLCs. The encapsulation efficiency and drug payload were higher for unsaturated lipid blends. In vitro release
studies indicate that the nature of the lipid matrix affects both the rate and release pattern. All UA-loaded formulations exhibited
superior anticancer activity compared to that of free UA against human leukemic cell line K562 and melanoma cell line B16
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| Publisher |
American Chemical Society
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| Date |
2016-09-02
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2564/1/Langmuir%2C_2016%2C_32_(38)%2C_pp_9816%E2%80%939825.pdf
Nahak, Prasant and Karmakar, Gourab and Chettri, Priyam and Roy, Biplab and Guha, Pritam and Besra, Shila Elizabeth and Soren, Anjana and Bykov, Alexey G and Akentiev, Alexander V and Noskov, Boris A and Panda, Amiya Kumar (2016) Influence of Lipid Core Material on Physicochemical Characteristics of an Ursolic Acid-Loaded Nanostructured Lipid Carrier: An Attempt to Enhance Anticancer Activity. Langmuir, 32 (38). pp. 9816-9825. |
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| Relation |
http://dx.doi.org/10.1021/acs.langmuir.6b02402
http://www.eprints.iicb.res.in/2564/ |
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