In-Silico Studies for Designing Potential Anti -alzheimer�s Disease Drug Candidates using Integrated Approaches
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
In-Silico Studies for Designing Potential Anti -alzheimer�s Disease Drug Candidates using Integrated Approaches
|
|
| Creator |
Prabhu, M
|
|
| Subject |
Molecular & Human Genetics
|
|
| Description |
More than one hundred years ago, a small group of psychiatrists described the abnormal protein deposits in the brain that define the most common neurodegenerative diseases. Over the past 30 years, it has become clear that the proteins forming the deposits are central to the
disease process. Aging is a major risk factor for neurodegenerative disorders, such as Alzheimer’s disease (AD) and Parkinson disease (PD). Among these, Alzheimer’s disease is the most common cause of dementia and has emerged as the most prevalent form of late-life
mental failure in humans. AD was first described by the German psychiatrist and neuropathologist Alois Alzheimer [1] in 1906 from whom it takes its name. He reported the
existence of two abnormal structures, senile plaques and neurofibrillary tangles, in the brain of his patient, a woman referred to as Auguste D. The symptoms, observed in his patient, exemplified several cardinal features of the disorder that is observed in AD patients even today, viz., progressive memory impairment, disordered cognitive function, altered behaviour including paranoia, delusions, and loss of social appropriateness, and a progressive decline in language function [2]. AD is a devastating and ultimately fatal neurodegenerative disease,
characterized by progressive cognitive and memory deterioration that leads to difficulty in carrying out everyday activities.
|
|
| Date |
2013
|
|
| Type |
Thesis
NonPeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/1988/1/prabu_PhD_thesis_final%2Dfull.pdf
Prabhu, M (2013) In-Silico Studies for Designing Potential Anti -alzheimer�s Disease Drug Candidates using Integrated Approaches. PhD thesis, Calcutta University. |
|
| Relation |
http://www.eprints.iicb.res.in/1988/
|
|