Interaction of RuIII(EDTA) with cellular thiols and O2: biological implications thereof
IR@CMERI: CSIR- Central Mechanical Engineering Research Institute (CMERI), Durgapur
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| Title |
Interaction of RuIII(EDTA) with cellular thiols and O2: biological implications thereof
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| Creator |
Chatterjee, Debabrata
Jaiswal, Namita K., Jagadish C. Bose Mahato, Ram Balak Bhattacharyya, Diptendu |
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| Subject |
Chemistry
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| Description |
Reaction of [RuIII(EDTA)(CyS)]2− (edta4− = ethylenediaminetetraacetate; CySH = cysteine) with molecular oxygen (O2) has been studied as a function of pH (4.0–8.0) and cysteine concentration (0.2–2.0 mM) at room temperature (25 °C). Biological activities of the [Ru(EDTA)]/CySH/O2 system pertaining to cleavage of supercoiled plasmid DNA to its nicked open circular form has been explored in this work. Results are discussed in regard to the reaction of the ruthenium(III)-complex with molecular oxygen) and a working mechanism is proposed for the biological activities of the ruthenium(III)-complex in the presence of O2.
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| Date |
2015
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| Type |
Article
PeerReviewed |
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| Identifier |
Chatterjee, Debabrata and Jaiswal, Namita and K., Jagadish C. Bose and Mahato, Ram Balak and Bhattacharyya, Diptendu (2015) Interaction of RuIII(EDTA) with cellular thiols and O2: biological implications thereof. Journal of Coordination Chemistry, 68 (17-18). pp. 3229-3235.
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| Relation |
http://cmeri.csircentral.net/235/
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