Molecular Basis of Neuroprotection Against Parkinsonism By Identified Ayurvedic Molecules
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Molecular Basis of Neuroprotection Against Parkinsonism By Identified Ayurvedic Molecules
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| Creator |
Singh, Raghavendra
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| Subject |
Cell Biology & Physiology
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| Description |
Parkinson’s disease (PD) is characterized by progressive and selective demise of mesencephalic substantia nigra pars compacta (SNpc) neurons with manifestation of motor
abnormalities including tremor, slowness in movement, rigidity and poor balance. Although L-3, 4- dihydroxy phenylalanine (L-DOPA) has been the mainstay of PD therapy,
which gives symptomatic relief in initial uses, yet it has severe side-effects on prolonged use, and causes on-off phenomenon, falls and L-DOPA-induced dyskinesia (Caillava-
Santos et al., 2015; Cenci, 2014; Metman et al., 1997; Sweet et al., 1975). Moreover, the drug does not show any beneficial effects on the natural progression of the disease.
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| Date |
2016-03-18
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2584/1/Raghavendra_Thesis.pdf
Singh, Raghavendra (2016) Molecular Basis of Neuroprotection Against Parkinsonism By Identified Ayurvedic Molecules. PhD thesis, C U. |
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| Relation |
http://www.eprints.iicb.res.in/2584/
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