Development of functionalised nanomaterials for delivery of multiple biomolecules into the cell
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Development of functionalised nanomaterials for delivery of multiple biomolecules into the cell
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| Creator |
Jana, Batakrishna
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| Subject |
Chemistry
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| Description |
The overall goal of this thesis is to design and synthesis of functionalized nanoparticles and their therapeutic application. The synthesis of functionalized nanoparticles has been fully characterized by various spectroscopic and microscopic techniques. These functionalized nanoparticles have been used for delivery of multiple biomolecules simultaneously into the cell. Moreover, kinesin mediated intracellular cargo transport has been reconstituted with these functionalized nanoparticles as well as it has been used as a delivery vehicle for enhancement of the anticancer efficacy of the antimitotic peptides as well as the microtubule targeted short DNA. At the end of this thesis, it has also been shown that cyclodextrin, which is commonly used as a delivery vehicle interacts with tubulin/microtubules and delivers tubulin targeted drugs into the tubulin surface and preferentially into the cancer cell.
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| Date |
2016-05-05
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2595/1/Thesis_Batakrishna_Jana.pdf
Jana, Batakrishna (2016) Development of functionalised nanomaterials for delivery of multiple biomolecules into the cell. PhD thesis, C U . |
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| Relation |
http://www.eprints.iicb.res.in/2595/
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