Chromatin Remodeling Protein SMAR1 Is a Critical Regulator of T Helper Cell Differentiation and Inflammatory Diseases
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Chromatin Remodeling Protein SMAR1 Is a Critical Regulator of T Helper Cell Differentiation and Inflammatory Diseases
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| Creator |
Mirlekar, Bhalchandra
Gautam, Dipendra Chattopadhyay, Samit |
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| Subject |
Cancer Biology and Inflammatory Disorder Division
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| Description |
T cell differentiation from naïve T cells to specialized effector subsets of mature cells is determined by the iterative action of transcription factors. At each stage of specificT cell lineage differentiation, transcription factor interacts not only with nuclear proteins
such as histone and histone modifiers but also with other factors that are bound to the chromatin and play a critical role in gene expression. In this review, we focus on one
of such nuclear protein known as tumor suppressor and scaffold matrix attachment region-binding protein 1 (SMAR1) in CD4+ T cell differentiation. SMAR1 facilitates Th1
differentiation by negatively regulating T-bet expression via recruiting HDAC1–SMRT complex to its gene promoter. In contrast, regulatory T (Treg) cell functions are dependent
on inhibition of Th17-specific genes mainly IL-17 and STAT3 by SMAR1. Here, we discussed a critical role of chromatin remodeling protein SMAR1 in maintaining a fine-tuned
balance between effector CD4+ T cells and Treg cells by influencing the transcription factors during allergic and autoimmune inflammatory diseases.
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| Date |
2017-02-09
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2612/1/FRONTIERS_IN_IMMUNOLOGY.pdf
Mirlekar, Bhalchandra and Gautam, Dipendra and Chattopadhyay, Samit (2017) Chromatin Remodeling Protein SMAR1 Is a Critical Regulator of T Helper Cell Differentiation and Inflammatory Diseases. Frontiers in Immunology, 8 (72). 01p.-11p.. |
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| Relation |
http://dx.doi.org/10.3389/fimmu.2017.00072
http://www.eprints.iicb.res.in/2612/ |
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