Carbon nanospheres mediated delivery of nuclear matrix protein SMAR 1 to direct experimental autoimmune encephalomyelitis in mice
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Carbon nanospheres mediated delivery of nuclear matrix protein SMAR 1 to direct experimental autoimmune encephalomyelitis in mice
|
|
| Creator |
Chemmannur, Sijo V
Bhagat, Prasad Mirlekar, Bhalchandra Paknikar, Kishore M Chattopadhyay, Samit |
|
| Subject |
Cancer Biology and Inflammatory Disorder Division
|
|
| Description |
Owing to the suppression of immune responses and associated side effects, steroid based treatments for inflammatory encephalitis disease can be detrimental. Here, we demonstrate a novel carbon nanosphere (CNP) based treatment regime for encephalomyelitis in mice by exploiting the functional property of the nuclear matrix binding protein SMAR1. A truncated part of SMAR1 ie, the DNA binding domain was conjugated with hydrothermally synthesized CNPs. When administered intravenously, the conjugate suppressed experimental animal encephalomyelitis in T cell specific conditional SMAR1 knockout mice (SMAR-/-). Further, CNP-SMAR1 conjugate delayed the onset of the disease and reduced the demyelination significantly. There was a significant decrease in the production of IL-17 after re-stimulation with MOG. Altogether, our findings suggest a potential carbon nanomaterial based therapeutic intervention to combat Th17 mediated autoimmune diseases including experimental autoimmune encephalomyelitis.
|
|
| Date |
2016-05-12
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://www.eprints.iicb.res.in/2616/1/International_Journal_of_Nanomedicine%2C_pdf.pdf
Chemmannur, Sijo V and Bhagat, Prasad and Mirlekar, Bhalchandra and Paknikar, Kishore M and Chattopadhyay, Samit (2016) Carbon nanospheres mediated delivery of nuclear matrix protein SMAR 1 to direct experimental autoimmune encephalomyelitis in mice. International Journal of Nanomedicine, 11. pp. 2039-2051. |
|
| Relation |
http://dx.doi.org/10.2147/IJN.S93571
http://www.eprints.iicb.res.in/2616/ |
|