A Smart Molecule for Selective Sensing of Nitric Oxide: Conversion of NO to HSNO; Relevance of Biological HSNO Formation
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
A Smart Molecule for Selective Sensing of Nitric Oxide: Conversion of NO to HSNO; Relevance of Biological HSNO Formation
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| Creator |
Islam, Abu Saleh Musha
Bhowmick, Rahul Pal, Kaberi Katarkar, Atul Chaudhuri, Keya Ali, Mahammad |
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| Subject |
Molecular & Human Genetics
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| Description |
A smart molecule, QT490, containing thiosemicarbazide
moiety acts as a highly selective turn-on in vitro NO sensor through the unprecedented NO-induced transformation of thiosemicarbazide moiety to 1,3,4-oxadiazole heterocycle with the concomitant release of HSNO, thereby eliminating any interference from various endogenous biomolecules including dehydroascorbic acid, ascorbic acid, etc. The
kinetic studies of the reactions between QT490 and NO provide a mechanistic insight into formation of HSNO/RSNO from the reaction between H2S/RSH and NO in the biological system. This novel probe is non-cytotoxic, cell permeable, water-soluble, and appropriate for intracellular cytoplasmic NO sensing with the possibilities of in vivo
applications.
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| Publisher |
American Chemical Society
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| Date |
2017-03-27
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2664/1/Inorganic_Chemistry%2C_KC%2C_2017.pdf
Islam, Abu Saleh Musha and Bhowmick, Rahul and Pal, Kaberi and Katarkar, Atul and Chaudhuri, Keya and Ali, Mahammad (2017) A Smart Molecule for Selective Sensing of Nitric Oxide: Conversion of NO to HSNO; Relevance of Biological HSNO Formation. Inorganic Chemistry, 56. pp. 4324-4331. ISSN 2017, 56, 4324−4331 |
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| Relation |
http://dx.doi.org/10.1021/acs.inorgchem.6b02787
http://www.eprints.iicb.res.in/2664/ |
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