[RuIII(EDTA)(H2O)]- mediated oxidation of cellular thiols by HSO5-
IR@CMERI: CSIR- Central Mechanical Engineering Research Institute (CMERI), Durgapur
View Archive Info| Field | Value | |
| Title |
[RuIII(EDTA)(H2O)]- mediated oxidation of cellular
thiols by HSO5-
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| Creator |
Sarkar, Papiya
Saha, Amrita Chatterjee, Debabrata |
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| Subject |
Chemistry
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| Description |
The [RuIII(EDTA)(H2O)]- (EDTA4-= ethylenediaminetetraacetate) complex is shown to mediate the oxidation of thiols, RSH (RSH = cysteine, glutathione, N-acetylcysteine, and penicillamine), with peroxomonosulfate ion (HSO5-). The kinetics of the catalytic oxidation process were studied using toppedflow
and rapid scan spectrophotometry as a function of [RuIII(EDTA)(H2O)-], [HSO5-], and [RSH] at a constant pH (6.2). Spectral analyses and kinetic data are suggestive of a catalytic pathway in which the RSH reacts with the [RuIII(EDTA)] catalyst complex to form [RuIII(EDTA)(SR)]2- intermediate species. In a subsequent step the HSO5- ion reacts directly with the coordinated S-atom of [RuIII(EDTA)(SR)]2- yielding the disulfido species, RSSR, as a major oxidation product (as identified using HPLC and ESI-MS analyses) under the employed conditions. Based on the experimental data, a working mechanism is proposed for the [RuIII(EDTA)] catalyzed oxidation of thiols.
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| Publisher |
Royal Society of Chemistry
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| Date |
2016
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| Type |
Article
PeerReviewed |
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| Identifier |
Sarkar, Papiya and Saha, Amrita and Chatterjee, Debabrata (2016) [RuIII(EDTA)(H2O)]- mediated oxidation of cellular thiols by HSO5-. New Journal of Chemistry, 40 (11). pp. 9380-9384.
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| Relation |
http://cmeri.csircentral.net/342/
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