Fish scale derived hydroxyapatite scaffold for bone tissue engineering
IR@CMERI: CSIR- Central Mechanical Engineering Research Institute (CMERI), Durgapur
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| Title |
Fish scale derived hydroxyapatite scaffold for bone tissue engineering
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| Creator |
Mondal, B.
Mondal, S. Mondal, A. Mandal, N. |
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| Subject |
Tissue engineering
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| Description |
The tailored mechanical characteristics of bioceramic scaffold are very important for the bone tissue engineering. Functional hydroxyapatite (HAp) synthesized from fish scale (Labio rohita & Catla catla) is explored as scaffold materials. HAp scaffold exhibits better mechanical properties such as hardness (~ 1.08 GPa), compressive strength (~ 0.8 GPa) and tensile strength (~ 187 MPa) with adequate porosity (~ 35%) compared to commercial and synthetic body fluid derived HAp. The in vitro assays (MTT, LDH and Trypan blue) with MG63 osteoblast cell lines reveal that fish scale derived HAp materials is non-toxic and bioactive. The in vivo histological analysis of implanted HAp scaffold shows the osteo-conductive characteristics. The findings are significant with respect to cytotoxicity, osteo-conductivity and mechanical stability during bio-mineralization of traumatized bone tissues.
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| Publisher |
Elsevier
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| Date |
2016-11
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| Type |
Article
PeerReviewed |
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| Identifier |
Mondal, B. and Mondal, S. and Mondal, A. and Mandal, N. (2016) Fish scale derived hydroxyapatite scaffold for bone tissue engineering. Materials Characterization, 121. pp. 112-124.
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| Relation |
http://cmeri.csircentral.net/372/
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