Biophysical studies on the interaction of the alkaloid chelerythrine with nucleic acids
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
Biophysical studies on the interaction of the alkaloid
chelerythrine with nucleic acids
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| Creator |
Basu, Pritha
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| Subject |
Chemistry
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| Description |
DNA-deoxyribonucleic acid is the blueprint for life. It is present in organisms ranging from
the smallest bacterium to the largest whale. DNA carries most of the genetic instructions
used in the development, functioning and reproduction of well known living organisms.
James Dewey Watson and Francis Harry Compton Crick had revolutionized the field of
molecular biology and medicine by proposing the structure of deoxyribonucleic acid through
model building studies in their celebrated paper published in the Nature magazine of April
23 (Watson and Crick, 1953). Although the Watson and Crick was known as father of DNA the
preliminary research on DNA was started many decades ago on 1868 by Swiss chemist
Friedrich Miescher. Miescher in 1868 detected a phosphorus-containing substance from the
nuclei of pus cells obtained from discarded surgical bandages. He named it ‘nuclein’ consisting
of an acidic portion which we know today as DNA. In 1878, Albrecht Kossel isolated the nonprotein
component of “nuclein”, the nucleic acid, and later isolated its five primary
nucleobases (Albrect, 1879). In 1919, Phoebus Levene identified the base, sugar and phosphate
nucleotide unit (Levene, 1919). Levene suggested that DNA consisted of a string of nucleotide
units linked together through the phosphate groups. Levene thought the chain was short and
the bases repeated in a fixed order. In 1937, William Astbury produced the first X-ray diffraction
pattern that showed that DNA had a regular structure (Astbury and Florence, 1938). In 1944
Oswald Avery and his coworkers discovered that DNA carries a cell’s genetic material and
can be altered through transformation
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| Date |
2016-09-21
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2701/1/Pritha_Basu_Thesis.pdf
Basu, Pritha (2016) Biophysical studies on the interaction of the alkaloid chelerythrine with nucleic acids. PhD thesis, J U. |
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| Relation |
http://www.eprints.iicb.res.in/2701/
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