C11/C9 Helical Folding in ab Hybrid Peptides Containing 1-Aminocyclohexane acetic acid (b3,3-Ac6c)
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
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| Title |
C11/C9 Helical Folding in ab Hybrid Peptides Containing 1-Aminocyclohexane acetic acid (b3,3-Ac6c)
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| Creator |
Wani, Naiem Ahmad
Raghothama, Srinivasarao Singh, Umesh Prasad Rai, Rajkishor |
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| Subject |
Nonlinear Dynamics
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| Description |
The present study describes the solid-state conformation
of ab hybrid peptides, Boc-Leu-b3,3-Ac6c-OH,
P1; Boc-Leu-b3,3-Ac6c-Leu-b3,3-Ac6c-OMe, P2; and Boc-Leub
3,3-Ac6c-Leu-b3,3-Ac6c-Leu-OMe, P3. The dipeptide P1
adopts extended conformations, whereas tetrapeptide P2
and pentapeptide P3 favor a helical conformation stabilized by mixed types of C11/C9 intramolecular hydrogen bonds. In peptide P3, the amino group of b3,3-Ac6c(2) and b3,3-Ac6c(4) residues occupies axial orientation, whereas in P2 it occupies axial and equatorial orientations for residues b3,3-Ac6c(2) and b3,3-Ac6c(4), respectively. The self-assembly of P3 forms channels filled with solvent molecules that present interesting patterns.
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| Date |
2017
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2710/1/CHEMISTRY%2DA_EUROPEAN_JOURNAL.pdf
Wani, Naiem Ahmad and Raghothama, Srinivasarao and Singh, Umesh Prasad and Rai, Rajkishor (2017) C11/C9 Helical Folding in ab Hybrid Peptides Containing 1-Aminocyclohexane acetic acid (b3,3-Ac6c). Chemistry-A EuropeanJournal, 23 (35). pp. 8364-8370. |
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| Relation |
http://www.eprints.iicb.res.in/2710/
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