Ruthenium(II)-catalyzed intermolecular synthesis of 2-arylindolines through C–H activation/ oxidative cyclization cascade
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Ruthenium(II)-catalyzed intermolecular synthesis of 2-arylindolines through C–H activation/ oxidative cyclization cascade
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| Creator |
Manna, Manash Kumar
Bhunia, Samir Kumar Jana, Ranjan |
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| Subject |
Chemistry
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| Description |
Herein, we report a ruthenium-catalyzed 1,2-carboamination through C–H activation for the synthesis of 2-arylindolines from readily available, inexpensive, protected anilines and vinyl arenes. In earlier reports, indoline synthesis through C–H activation was
demonstrated using sterically or electronically biased olefins suppressing b-hydride elimination. However, in the present protocol a ruthenium(II)-catalyzed indoline synthesis via interrupted Heck-type manifold with unbiased styrenes is demonstrated. Mechanistically, the
reaction proceeds through pyrimidine directed electrophilic ortho metalation, alkene insertion, amine coordination, and reductive elimination to construct the indoline nucleus
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| Publisher |
Royal Society of Chemistry
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| Date |
2017-06-28
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2711/1/Chem._Commun.%2C_2017%2C_53%2C_6906%2D%2D6909.pdf
Manna, Manash Kumar and Bhunia, Samir Kumar and Jana, Ranjan (2017) Ruthenium(II)-catalyzed intermolecular synthesis of 2-arylindolines through C–H activation/ oxidative cyclization cascade. Chemical Communications, 53 (51). pp. 6906-6909. |
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| Relation |
http://dx.doi.org/10.1039/C7CC03053C
http://www.eprints.iicb.res.in/2711/ |
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