Interaction of hydroalcoholic extract of <i style="mso-bidi-font-style:normal">Acorus calamus</i> Linn. with sodium valproate and carbamazepine
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Interaction of hydroalcoholic extract of <i style="mso-bidi-font-style:normal">Acorus calamus</i> Linn. with sodium valproate and carbamazepine
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| Creator |
Katyal, Jatinder
Sarangal, Vikas Gupta, Yogendra Kumar |
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| Subject |
<i style="mso-bidi-font-style:normal"><span style="font-size:11.0pt;font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Mangal; mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language:HI" lang="EN-GB">Acorus calamus</span></i>
Carbamazepine Pentylenetetrazole-induced seizures Sodium valproate |
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| Description |
51-55
Anticonvulsant property of <i style="mso-bidi-font-style:normal">Acorus calamus</i> is known. Since combination therapy can lower the dose of individual drug and dose related toxicities, in this study, the effect of co-administration of hydroalcoholic extract of <i style="mso-bidi-font-style:normal">A. calamus</i> (HAEAC) on conventional antiepileptic drugs (AEDs), sodium valproate and carbamazepine was determined using pentylenetetrazole -induced seizures model in rats. On combining the subanticonvulsant doses of HAEAC with sodium valproate and carbamazepine, greater protection as compared to either drug alone was observed. This was not related to change in levels of the AEDs. Thus, the results further substantiate anticonvulsant effect of HAEAC and suggest a potential for add on therapy with AEDs. |
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| Date |
2012-01-02T05:58:31Z
2012-01-02T05:58:31Z 2012-01 |
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| Type |
Article
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| Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://hdl.handle.net/123456789/13310 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJEB Vol.50(01) [January 2012]
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