<span style="font-size:11.0pt;font-family: "Times New Roman","serif";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language: HI" lang="EN-GB">Staurosporine induced poly (ADP-ribose) polymerase independent cell death in <i style="mso-bidi-font-style:normal">Dictyostelium discoideum</i></span>
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
<span style="font-size:11.0pt;font-family: "Times New Roman","serif";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language: HI" lang="EN-GB">Staurosporine induced poly (ADP-ribose) polymerase independent cell death in <i style="mso-bidi-font-style:normal">Dictyostelium discoideum</i></span>
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| Creator |
Mir, Hina
Rajawat, Jyotika Begum, Rasheedunnisa |
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| Subject |
Apoptosis inducing factor
Benzamide Cathepsin Pepstatin Staurosporine |
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| Description |
80-86
In the present study <i style="mso-bidi-font-style: normal">D. discoideum </i>has been used as a model organism to understand the role of poly (ADP-ribose) polymerase (PARP) in caspase independent paraptotic cell death pathways. <i style="mso-bidi-font-style:normal">D. discoideum</i> lacks caspases and Bcl-2 family proteins; nevertheless it has 9 potential genes for PARP. PARP has been known to get activated in various cell death associated diseases. In this study kinetics of cell death induced by staurosporine (STS), a bacterial alkaloid, was established to unravel the role of PARP. It was found that STS induced cell death in <i style="mso-bidi-font-style:normal">D. discoideum</i> did not involve PARP activation, however it involved cathepsin D. Results indicated that an alternative mechanism may be existing in <i style="mso-bidi-font-style:normal">D. discoideum </i>that<i style="mso-bidi-font-style: normal"> </i>lacks Bcl-2 family proteins for STS induced cell death that evades Bax involvement. |
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| Date |
2012-01-02T06:01:01Z
2012-01-02T06:01:01Z 2012-01 |
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| Type |
Article
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| Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://hdl.handle.net/123456789/13315 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJEB Vol.50(01) [January 2012]
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