Rational design, synthesis, SAR study of N-napthalen-1-yl-2-[4-(substituted phenyl)-piperazin-1-yl]-acetamides as atypical antipsychotic agents
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Rational design, synthesis, SAR study of N-napthalen-1-yl-2-[4-(substituted phenyl)-piperazin-1-yl]-acetamides as atypical antipsychotic agents
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| Creator |
Sati, N
Kumar, S Rawat, M S M |
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| Subject |
N-Napthalen-1-yl acetamide
Serotonin antagonists arylpiperazines Dopamine antagonists Atypical antipsychotic |
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| Description |
318-322
Design and synthesis of various N-napthalen-1-yl-2-[4-(substituted phenyl)-piperazin-1-yl]-acetamides have been carried out on the basis of structural information available for dopamine D<sub>3</sub> and serotonin receptor and screened for antagonist activity at the target receptors and atypical antipsychotic profile. The series synthesized affords compounds having varying degree of affinity for target receptors. N-napthalen-1-yl-2-[4-(2-methoxy phenyl)-piperazin-1-yl]-acetamide <b style="mso-bidi-font-weight:normal">1e</b> is found to be the most potent atypical antipsychotic compound synthesized. |
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| Date |
2012-01-14T19:05:04Z
2012-01-14T19:05:04Z 2012-01 |
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| Type |
Article
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| Identifier |
0975-0983(Online); 0376-4699(Print)
http://hdl.handle.net/123456789/13400 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJC-B Vol.51B(01) [January 2012]
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