PEPlife: A Repository of the Half-life of Peptides
IR@IMTECH: CSIR-Institute of Microbial Technology, Chandigarh
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| Title |
PEPlife: A Repository of the Half-life of Peptides
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| Creator |
Mathur, Deepika
Prakash, Satya Anand, Priya Kaur, Harpreet Agrawal, Piyush Mehta, Ayesha Kumar, Rajesh Singh, Sandeep Raghava, G.P.S. |
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| Subject |
QR Microbiology
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| Description |
Short half-life is one of the key challenges in the field of therapeutic peptides. Various studies have reported enhancement in the stability of peptides using methods like chemical modifications, D-amino acid substitution, cyclization, replacement of labile aminos acids, etc. In order to study this scattered data, there is a pressing need for a repository dedicated to the half-life of peptides. To fill this lacuna, we have developed PEPlife (http://crdd.osdd.net/raghava/peplife), a manually curated resource of experimentally determined half-life of peptides. PEPlife contains 2229 entries covering 1193 unique peptides. Each entry provides detailed information of the peptide, like its name, sequence, half-life, modifications, the experimental assay for determining half-life, biological nature and activity of the peptide. We also maintain SMILES and structures of peptides. We have incorporated web-based modules to offer user-friendly data searching and browsing in the database. PEPlife integrates numerous tools to perform various types of analysis such as BLAST, Smith-Waterman algorithm, GGSEARCH, Jalview and MUSTANG. PEPlife would augment the understanding of different factors that affect the half-life of peptides like modifications, sequence, length, route of delivery of the peptide, etc. We anticipate that PEPlife will be useful for the researchers working in the area of peptide-based therapeutics.
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| Publisher |
Nature Publishing Group
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| Date |
2016
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| Type |
Article
PeerReviewed |
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| Relation |
http://dx.doi.org/10.1038/srep36617
http://crdd.osdd.net/open/1975/ |
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| Identifier |
Mathur, Deepika and Prakash, Satya and Anand, Priya and Kaur, Harpreet and Agrawal, Piyush and Mehta, Ayesha and Kumar, Rajesh and Singh, Sandeep and Raghava, G.P.S. (2016) PEPlife: A Repository of the Half-life of Peptides. Scientific Reports, 6 (1). ISSN 2045-2322
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