β-Endorphin enhances the phospholipase activity of the dandruff causing fungiMalassezia globosaandMalassezia restricta
IR@IMTECH: CSIR-Institute of Microbial Technology, Chandigarh
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| Title |
β-Endorphin enhances the phospholipase activity of the dandruff causing fungiMalassezia globosaandMalassezia restricta
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| Creator |
Honnavar, Prasanna
Chakrabarti, Arunaloke Prasad, Ghandam S Singh, Pankaj Dogra, Sunil Rudramurthy, Shivaprakash M |
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| Subject |
QR Microbiology
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| Description |
β-Endorphin is known to stimulate phospholipase production by Malassezia pachydermatis during canine dermatoses. The role of β-endorphin in Malassezia infection in humans is not well studied. The present study compares the influence of β-endorphin on Malassezia globosa and Malassezia restricta isolated from patients with seborrhoeic dermatitis/dandruff (SD/D) and healthy controls. Malassezia isolates (five each of the two species from patients and healthy controls) were grown on modified Dixon's agar with or without 100 nmol/L β-endorphin. Phospholipase activity was quantified based on its ability to hydrolyze L-α-phosphatidylcholine dimyristoyl (phospholipid substrate). Free fatty acid was measured by a colorimetry method. In isolates from patients, the phospholipase activity significantly increased after exposure to β-endorphin (M. globosa, P = .04; M. restricta, P = .001), which did not occur in isolates from healthy controls. Moreover, after β-endorphin exposure the patient isolates had significantly higher (P = .0004) phospholipase activity compared to the healthy control isolates. The results suggest that isolates of M. globosa and M. restricta from patients may differ from those of healthy humans.
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| Publisher |
Blackwell Science
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| Date |
2016
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| Type |
Article
PeerReviewed |
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| Relation |
http://dx.doi.org/10.1093/mmy/myw058
http://crdd.osdd.net/open/1959/ |
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| Identifier |
Honnavar, Prasanna and Chakrabarti, Arunaloke and Prasad, Ghandam S and Singh, Pankaj and Dogra, Sunil and Rudramurthy, Shivaprakash M (2016) β-Endorphin enhances the phospholipase activity of the dandruff causing fungiMalassezia globosaandMalassezia restricta. Medical Mycology, 55 (2). pp. 150-154. ISSN 1369-3786
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