Reinforcing the Functionality of Mononuclear Phagocyte System to Control Tuberculosis
IR@IMTECH: CSIR-Institute of Microbial Technology, Chandigarh
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| Title |
Reinforcing the Functionality of Mononuclear Phagocyte System to Control Tuberculosis
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| Creator |
Pahari, Susanta
Kaur, Gurpreet Negi, Shikha Aqdas, Mohammad Das, Deepjyoti K. Bashir, Hilal Singh, Sanpreet Nagare, Mukta Khan, Junaid Agrewala, J N |
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| Subject |
QR Microbiology
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| Description |
The mononuclear phagocyte system (MPS) constitutes dendritic cells, monocytes, and macrophages. This system contributes to various functions that are essential for maintaining homeostasis, activation of innate immunity, and bridging it with the adaptive immunity. Consequently, MPS is highly important in bolstering immunity against the pathogens. However, MPS is the frontline cells in destroying Mycobacterium tuberculosis (Mtb), yet the bacterium prefers to reside in the hostile environment of macrophages. Therefore, it may be very interesting to study the struggle between Mtb and MPS to understand the outcome of the disease. In an event when MPS predominates Mtb, the host remains protected. By contrast, the situation becomes devastating when the pathogen tames and tunes the host MPS, which ultimately culminates into tuberculosis (TB). Hence, it becomes extremely crucial to reinvigorate MPS functionality to overwhelm Mtb and eliminate it. In this article, we discuss the strategies to bolster the function of MPS by exploiting the molecules associated with the innate immunity and highlight the mechanisms involved to overcome the Mtb-induced suppression of host immunity. In future, such approaches may provide an insight to develop immunotherapeutics to treat TB.
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| Publisher |
Frontiers Research Foundation
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| Date |
2018-02-09
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| Type |
Article
PeerReviewed |
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| Relation |
http://dx.doi.org/10.3389/fimmu.2018.00193
http://crdd.osdd.net/open/2019/ |
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| Identifier |
Pahari, Susanta and Kaur, Gurpreet and Negi, Shikha and Aqdas, Mohammad and Das, Deepjyoti K. and Bashir, Hilal and Singh, Sanpreet and Nagare, Mukta and Khan, Junaid and Agrewala, J N (2018) Reinforcing the Functionality of Mononuclear Phagocyte System to Control Tuberculosis. Frontiers in Immunology, 9. ISSN 1664-3224
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