CSIR Central

THPdb: Database of FDA-approved peptide and protein therapeutics

IR@IMTECH: CSIR-Institute of Microbial Technology, Chandigarh


Field	Value

Title	THPdb: Database of FDA-approved peptide and protein therapeutics

Creator	Sang, Qing-Xiang Amy Usmani, Salman Sadullah Bedi, Gursimran Samuel, Jesse S. Singh, Sandeep Kalra, Sourav Kumar, Pawan Ahuja, Anjuman Arora Sharma, Meenu Gautam, Ankur Raghava, G.P.S.

Subject	QR Microbiology

Description	THPdb (http://crdd.osdd.net/raghava/thpdb/) is a manually curated repository of Food and Drug Administration (FDA) approved therapeutic peptides and proteins. The information in THPdb has been compiled from 985 research publications, 70 patents and other resources like DrugBank. The current version of the database holds a total of 852 entries, providing comprehensive information on 239 US-FDA approved therapeutic peptides and proteins and their 380 drug variants. The information on each peptide and protein includes their sequences, chemical properties, composition, disease area, mode of activity, physical appearance, category or pharmacological class, pharmacodynamics, route of administration, toxicity, target of activity, etc. In addition, we have annotated the structure of most of the protein and peptides. A number of user-friendly tools have been integrated to facilitate easy browsing and data analysis. To assist scientific community, a web interface and mobile App have also been developed.

Publisher	Public Library of Science

Date	2017

Type	Article PeerReviewed

Relation	http://dx.doi.org/10.1371/journal.pone.0181748 http://crdd.osdd.net/open/2028/

Identifier	Sang, Qing-Xiang Amy and Usmani, Salman Sadullah and Bedi, Gursimran and Samuel, Jesse S. and Singh, Sandeep and Kalra, Sourav and Kumar, Pawan and Ahuja, Anjuman Arora and Sharma, Meenu and Gautam, Ankur and Raghava, G.P.S. (2017) THPdb: Database of FDA-approved peptide and protein therapeutics. PLOS ONE, 12 (7). e0181748. ISSN 1932-6203