Understanding the molecular mechanisms of induction of oxidative stress and insulin resistance due to the treatment of free fatty acid and high fat diet in vitro and in vivo models
IR@IICB: CSIR-Indian Institute of Chemical Biology, Kolkata
View Archive Info| Field | Value | |
| Title |
Understanding the molecular mechanisms of
induction of oxidative stress and insulin
resistance due to the treatment of free fatty acid
and high fat diet in vitro and in vivo models
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| Creator |
Das, Nabanita
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| Subject |
Cell Biology & Physiology
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| Description |
Obesity has become the predominant health burden affecting over a third of the world’s population today. Obesity is a complicated multifactorial and
multi organ-centric disease that has been fueled by economic growth, sedentary lifestyle, urbanization and nutritional adaptation to calorie rich diets and processed food. Several complex metabolic diseases of heterogeneous etiology are associated
with obesity; type 2 diabetes mellitus (T2DM) is one of such predominant disorders.
Metabolic hallmark of T2DM is insulin resistance, the proposed underlying link between sedentary lifestyle and metabolic syndrome. The understanding of its
complex etiology and a proper detailed overview of its perplexing mechanisms can pave the way towards its therapeutics. As the pathophysiology of T2DM apart from
pancreatic β-cells, mainly surrounds liver and peripheral insulin target tissues i.e.,skeletal muscle, the current study has been focused on deciphering the metabolic
mechanisms in these organs. Moreover, increased oxidative stress has always appreciated as an inimical factor leading to insulin resistance in these tissues. The
present investigation has been designed to study metabolic contrivances behind reactive oxygen species generation during insulin resistance.
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| Date |
2017
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| Type |
Thesis
NonPeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://www.eprints.iicb.res.in/2752/1/Nabanita_Thesis.pdf
Das, Nabanita (2017) Understanding the molecular mechanisms of induction of oxidative stress and insulin resistance due to the treatment of free fatty acid and high fat diet in vitro and in vivo models. PhD thesis, Jadavpur University. |
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| Relation |
http://www.eprints.iicb.res.in/2752/
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