Sulfonylurea derivatives of tolbutamide analogues: Synthesis and evaluation of antimicrobial and antioxidant activities
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Sulfonylurea derivatives of tolbutamide analogues: Synthesis and evaluation of antimicrobial and antioxidant activities
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| Creator |
Ramudu, D B Janaki
Babu, Pulluru Hari Venkateswarlu, Nagam Vijaya, Tartti Rasheed, S Raju, Chamarthi Naga Chalapathi, Ponne Venkata |
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| Subject |
Sulfonylurea derivatives
Tolbutamide analogues Antibacterial Antifungal activities Antioxidant activities |
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| Description |
127-135
A series of new sulfonylurea derivatives of tolbutamide analogues have been synthesized in a simple and effective way in high yields to explore the possibilities of some altered biological actions such as antibacterial, antifungal and antioxidant activities (DPPH, H<sub>2</sub>O<sub>2</sub> and IC<sub>50</sub> values). Structures of these compounds have been well established by IR, <sup>1</sup>H and <sup>13</sup>C NMR, mass spectra and elemental analysis. Among the compounds 9c and 9j show promising antimicrobial activity. Compounds <strong>9a</strong>, <strong>9j</strong> and <strong>9d</strong> exhibit good antioxidant activity with lowest IC<sub>50</sub> values and close to the standard drug, ascorbic acid. Biological data reveals that sulfonylurea derivatives show good antioxidant activity rather than antimicrobial activity. |
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| Date |
2018-01-11T09:42:36Z
2018-01-11T09:42:36Z 2018-01 |
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| Type |
Article
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| Identifier |
0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/43412 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJC-B Vol.57B(01) [January 2018]
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