Synthesis and biological activities of nicotinaldehyde based azlactones
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Synthesis and biological activities of nicotinaldehyde based azlactones
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| Creator |
Dayakar, Ch
Mounika, L Rajkumar, K Zehra, A Murthy, T R Kalivendi, Shasi V Tiwari, A K Raju, B China |
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| Subject |
Nicotinaldehydes
Azlactones DPPH ABTS<sup>+.</sup>radical scavenging activity α-glucosidase inhibition Anti-proliferative activity |
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| Description |
98-107
A series of nicotinaldehyde based azlactones <strong>3a-g</strong>, <strong>6a-f</strong>, <strong>11a-d</strong>, <strong>16b-c</strong>, and <strong>16e-f</strong> have been prepared and screened for their free radicals scavenging, α-glucosidase inhibitory and anti-proliferative activities on cell lines, namely lung adenocarcinoma (A549), human breast cancer (MCF7) and human epithelial cervical cancer (HeLa). Compound <strong>3g</strong> is the most potent α-glucosidase inhibitor followed by compounds <strong>6b</strong> and <strong>6a</strong>. Compound <strong>11b</strong> is the better DPPH and ABTS<sup>+</sup> radical scavenger. Compounds <strong>11c-d</strong> and <strong>16f</strong> show anti-proliferative activity on all the tested cell lines. However, compounds <strong>16c</strong> and <strong>16e</strong> display anti-proliferative activity on MCF7 and HeLa cell lines. |
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| Date |
2018-01-11T10:09:05Z
2018-01-11T10:09:05Z 2018-01 |
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| Type |
Article
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| Identifier |
0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/43415 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJC-B Vol.57B(01) [January 2018]
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