Oxovanadium(IV) complexes of polypyridyl bases as photocytotoxic and DNA crosslinking agents
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Oxovanadium(IV) complexes of polypyridyl bases as photocytotoxic and DNA crosslinking agents
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| Creator |
Kumar, Arun
Dixit, Akanksha Banerjee, Samya Mukherjee, Sanjoy Sahoo, Somarupa Karande, Anjali A Chakravarty, Akhil R |
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| Subject |
Bioinorganic chemistry
Photocytotoxicity Cytotoxicity DNA crosslinks DNA cleavage Vanadium Polypyridyl bases |
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| Description |
409-417
Dichlorooxovanadium(IV) complexes of polypyridyl bases (B), viz., [VO(B)Cl<sub>2</sub>] (<strong>1</strong> and <strong>2</strong>) of <em>N,N,N</em>-donor ligands 2-(2-pyridyl)-1,10-phenanthroline (pyphen in <strong>1</strong>) and 3-(pyridin-2-yl)dipyrido[3,2-a:2',3'-c]phenazine (pydppz in <strong>2</strong>) have been prepared, and their anticancer activity studied. The complexes show good solubility in most polar solvent and are non-electrolytes. They show 1:1 electrolytic property in 20% aqueous DMF, and 1:2 electrolytic character in 20% aqueous DMF upon photo-irradiation with visible light (400–700 nm). Complex <strong>1</strong> shows DNA crosslinking property on dissociation of the V-Cl bond(s) as ascertained from its DNA melting profile and ethidium bromide displacement assay. The complexes <strong>1</strong> and <strong>2 </strong> are photocytotoxic towards HeLa (IC<sub>50</sub>: 16.9 µM and 0.87 µM respectively) and MCF-7 (IC<sub>50</sub>: 19.5 µM and 1.4 µM respectively) cancer cells, but exhibit less toxicity in normal embryonic fibroblast 3T3 cells with IC<sub>50</sub> values of ~40 and ~25 µM in visible light (400-700 nm) for complexes <strong>1</strong> and <strong>2</strong> respectively. Complex <strong>2</strong> also displays light induced plasmid DNA cleavage activity. The light-induced cellular damage leads to generation of reactive oxygen species followed by apoptotic cell death. |
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| Date |
2018-03-22T07:31:02Z
2018-03-22T07:31:02Z 2018-03 |
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| Type |
Article
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| Identifier |
0975-0975(Online); 0376-4710(Print)
http://nopr.niscair.res.in/handle/123456789/43986 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJC-A Vol.57A(03) [March 2018]
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