Protective effect of <em>Solanum torvum</em> on monosodium glutamate-induced neurotoxicity in mice
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Protective effect of <em>Solanum torvum</em> on monosodium glutamate-induced neurotoxicity in mice
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| Creator |
Mohan, Mahalaxmi
Gangurde, Sushilkumar Kadam, Vrushali |
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| Subject |
Excitotoxicity
Monosodium glutamate Neurotoxicity Oxidative stress <i>Solanum torvum</i> |
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| Description |
351-359
<em>Solanum torvum</em> is a well known traditional herbal medicinal plant used in many neurological disorders. The objective of the study was to evaluate the effects of <em>S. torvum</em> on monosodium glutamate (MSG) induced neurotoxicity. Swiss albino mice received MSG (1000 mg/kg, p.o) followed by a methanolic and hydroalcoholic extract of <em>S. torvum</em> (100 and 300 mg/kg, p.o) for 14 days. MSG-treated mice showed significant (<em>p</em><0.05) behavioural changes, decrease in relative organ weight of brain, a decrease in antioxidant enzyme levels and significant (<em>p</em><0.05) increase in lipid peroxidation in brain tissue. Histopathological changes observed in brain tissue were vacuolated cells, pyknotic nuclei, decreased neuronal density and distorted layers of brain tissue. Both extracts of <em>S. torvum</em> (100 and 300 mg/kg) showed normal behavior, significant (<em>p</em><0.05) increase in relative organ weight of brain, significant (<em>p</em><0.05) decrease in lipid peroxidation (LPO) and significant (<em>p</em><0.05) increase in reduced glutathione (RGSH), superoxide dismutase (SOD) and catalase (CAT) concentration in brain tissue as compared to MSG-treated mice. Treatment with <em>S. torvum</em> extracts reversed the histopathological changes induced by MSG. The study suggests that <em>S. torvum</em> seed extracts have the potential to ameliorate neuronal damage induced by MSG. Total flavonoid content of methanolic and hydroalcoholic extract of <em>S. torvum</em> was found to be 44±1.2 and 32±0.8 µg of rutin equivalent/mg of extracts and total phenolic content was found to be 70±0.28 and 52±0.62 µg of gallic acid equivalent/mg of extracts respectively. |
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| Date |
2018-03-28T10:17:16Z
2018-03-28T10:17:16Z 2017-12 |
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| Type |
Article
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| Identifier |
0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscair.res.in/handle/123456789/44137 |
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| Language |
en_US
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| Relation |
Int. cl. (2015.01)−A61K 36/00
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJNPR Vol.8(4) [December 2017]
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