Anti-cancer Investigation of Newly Derived Alicyclic ring and Morpholine Supported Hybrid Molecules by Industrially viable Route
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Anti-cancer Investigation of Newly Derived Alicyclic ring and Morpholine Supported Hybrid Molecules by Industrially viable Route
|
|
| Creator |
Kapadiya, K
Pandya, M Rathod, C Dhalani, J Dhaduk, B |
|
| Subject |
Cyclopropane
Anticancer Screening Ugi Multicomponent Reaction Morpholinoethyl Isocyanide |
|
| Description |
219-224
In an attempt to design and synthesize a new class of anticancer molecules, we have reported coupling of aryl aldehyde, <em>p</em>-toluidine and morpholine based isocyanide with cyclopropane carboxylic acid to generate a small library of 08 compounds (5a-5h) by ugi multicomponent reaction in a single step manner. Structures of the newly synthesized compounds were recognized on the basis of spectral data <em>i.e.</em> <sup>1</sup>H NMR, <sup>13</sup>C NMR, IR and Mass. These compounds were screened for their anticancer activity against nine basic panels as well as NCI-60 cell-lines. <em>In vitro </em> anticancer studies revealed that the compound 5ashowed maximum potency against HCT-116 in colon cancer cell lines with GI<sub>50</sub> values 46.27 µg/ml. |
|
| Date |
2018-04-04T08:48:39Z
2018-04-04T08:48:39Z 2018-04 |
|
| Type |
Article
|
|
| Identifier |
0975-1084 (Online); 0022-4456 (Print)
http://nopr.niscair.res.in/handle/123456789/44150 |
|
| Language |
en_US
|
|
| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
|
|
| Publisher |
NISCAIR-CSIR, India
|
|
| Source |
JSIR Vol.77(04) [April 2018]
|
|