Microwave assisted synthesis and SAR studies of novel hybrid phenothiazine analogs as potential antitubercular agents
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Microwave assisted synthesis and SAR studies of novel hybrid phenothiazine analogs as potential antitubercular agents
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| Creator |
Pemmadi, Raghuveer Varma
Kurre, Purna Nagasree Guruvelli, Padma Vijaya Sangeetha Jamullamudi, Risy Namratha Muthyala, Murali Krishna Kumar |
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| Subject |
Tuberculosis
Phenothiazine Anti-psychotic Anti-tubercular Hybrid pharmacophores Microwave assisted synthesis |
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| Description |
556-566
The present work has been initiated based on the interest driven by phenothiazine based neuroleptics with a special focus on thioridazine. Their clinically useful spectrum of anti-TB profile is the motivating factor. A hybrid pharmacophore has been designed containing phenothiazine nucleus and the synthetic reaction conditions have been optimized successfully with the help of a microwave synthesizer. Among the 60 synthesized compounds <strong>4b</strong>, <strong>4e</strong>, <strong>4i</strong> and <strong>4n</strong> show potent <em>in vitro</em> anti TB activity with an MIC 6.25 µg/mL and selectivity index >10. |
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| Date |
2018-04-12T05:50:12Z
2018-04-12T05:50:12Z 2018-04 |
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| Type |
Article
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| Identifier |
0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/44179 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJC-B Vol.57B(04) [April 2018]
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