Synthesis and <em>in vitro</em> studies of thiazolidine-4-carboxylic acid hydrazones as potential antitubercular agents
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Synthesis and <em>in vitro</em> studies of thiazolidine-4-carboxylic acid hydrazones as potential antitubercular agents
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| Creator |
Nagasree, Kurre Purna
Kumar, Muthyala Murali Krishna Prasad, Yejella Rajendra Sriram, Dharmarajan Yogeeswari, Perumal |
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| Subject |
Thiazolidine-4-carboxylic acid hydrazones
Antitubercular Multidrug resistant tuberculosis |
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| Description |
538-555
A series of forty six 2-substituted aryl-thiazolidine-4-carboxylic acid hydrazones (<strong>6a-c, 7a-c, 8a-c, 9a-c</strong> series) have been synthesized and isolated in their pure isomeric form (2<em>R</em>, 4<em>R</em> and 2<em>S</em>, 4<em>R</em>). Purity and structures have been ascertained by chromatographic and, IR, NMR and mass spectral data analysis. Antitubercular activity screening of these synthesized compounds against <em>Mycobacterium tuberculosis</em> H37Rv (MTB) and multi-drug resistant <em>Mycobacterium tuberculosis</em> (MDR-TB) has resulted in identification of three active compounds (<strong>6a 11, 6a 13, 6a 15</strong>) with MIC < 10 μM against MTB and MDR-TB. The compound <strong>6a 11</strong> (2<em>R</em>, 4<em>R</em> isomer) shows the highest potency with MIC 1.33 μM against MDR-TB. It is observed that the antitubercular activity of 2<em>R</em> isomer is four times more than the corresponding 2<em>S </em> isomer. |
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| Date |
2018-04-12T05:59:03Z
2018-04-12T05:59:03Z 2018-04 |
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| Type |
Article
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| Identifier |
0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/44180 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJC-B Vol.57B(04) [April 2018]
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