GC–MS analysis of essential oil of <em>Pinus roxburghii</em> Sarg. (Chir pine) needles and evaluation of antibacterial and anti-proliferative properties
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
GC–MS analysis of essential oil of <em>Pinus roxburghii</em> Sarg. (Chir pine) needles and evaluation of antibacterial and anti-proliferative properties
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| Creator |
Bhagat, Madhulika
Bandral, Anuj Bashir, Mudassar Bindu, Kushal |
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| Subject |
Antibacterial
Cytotoxic Essential oil Needles <i>Pinus roxburghii</i> |
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| Description |
34-38
The present study was carried out to analyse the biological properties and chemical composition by GC-MS analysis of the essential oil of the needles of <em>Pinus roxburghii</em>. Sixteen components were identified from their fragmentation pattern in the essential oil. Major component present in the essential oil belonged to monoterpene (84.38 %), oxygenated monoterpene (4.23 %) and Sesquiterperne (11.35 %) category. The antibacterial potential was analysed by paper disc diffusion assay against 5 gram-positive bacteria and 5 gram-negative bacteria. Oil showed a broad spectrum of activity by inhibiting all the 5 gram-positive bacteria and 2 gram-negative bacteria viz., <em>Escherichia coli</em> and <em>Campylobacter coli</em>. The antiproliferative property was measured against A-549 (lung), T98G (glioblastoma), PC-3 (prostate) and T47D (breast) human cancer cell lines by Sulphorhodamine-B assay. Here, the essential oil exhibited cytotoxic properties against human cancer cell lines with IC<sub>50</sub> values of 161.30 μg/mL and 154.30 μg/mL for A549 and T98G respectively. The results suggest that active component of the essential oil of <em>Pinus roxburghii</em> possess antimicrobial and antiproliferative properties which may be useful for food preservation, pharmaceutical treatment and natural therapies. |
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| Date |
2018-07-03T12:32:09Z
2018-07-03T12:32:09Z 2018-03 |
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| Type |
Article
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| Identifier |
0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscair.res.in/handle/123456789/44640 |
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| Language |
en_US
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| Relation |
Int. cl. (2015.01)− A61K 36/00, 36/15, A61P 31/04
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJNPR Vol.9(1) [March 2018]
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