Synthesis and biological evaluation of some novel quinoline based pyrimidine derivatives
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Synthesis and biological evaluation of some novel quinoline based pyrimidine derivatives
|
|
| Creator |
Desai, N C
Kotadiya, G M Vaja, D V |
|
| Subject |
Quinoline clubbed pyrimidines
Antibacterial activity Antifungal activity Cytotoxicity MIC |
|
| Description |
965-973
A rational approach has been adopted for the synthesis of novel series of 3-((6-(2-chloro-6-methoxyquinolin-3-yl)-4-aryl-1,6-dihydropyrimidin-2-yl)thio)propanenitriles <strong>5a-o</strong>. The synthesized compounds have been evaluated for their <em>in vitro </em>antimicrobial activity. Compounds <strong>5j-m</strong> display broad spectrum antibacterial activity against all the bacterial strains. Moreover, compound <strong>5m</strong> is found to be the most potent antibacterial and antifungal agent. Further, the results of preliminary MTT cytotoxicity studies on HeLa cells suggest that potent antimicrobial activity of <strong>5j-m</strong> is accompanied by low level of cytotoxicity. |
|
| Date |
2018-07-23T06:42:53Z
2018-07-23T06:42:53Z 2018-07 |
|
| Type |
Article
|
|
| Identifier |
0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/44748 |
|
| Language |
en_US
|
|
| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
|
|
| Publisher |
NISCAIR-CSIR, India
|
|
| Source |
IJC-B Vol.57B(07) [July 2018]
|
|