Synthesis and biological evaluation of some new furoxan derivatives as anti-inflammatory agents
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Synthesis and biological evaluation of some new furoxan derivatives as anti-inflammatory agents
|
|
| Creator |
Amir, Mohd
Verma, Jeevan S Tariq, Sana Somakala, K Ehtaishamul Haq, S |
|
| Subject |
Furoxan
Nitric oxide donor Anti-inflammatory Ulcerogenicity |
|
| Description |
955-959
A new series of furoxan derivatives (<strong>3a-k</strong>) have been synthesized and characterized by their IR, <sup>1</sup>HÂ NMR and mass spectral data. All the compounds have been screened for their anti-inflammatory activity. The compounds <strong>3a</strong>, <strong>3b</strong>, <strong>3f</strong>, <strong>3g</strong>, and <strong>3i</strong> which show significant anti-inflammatory activity have been further studied for their ulcerogenic activities and nitric oxide releasing properties. Furoxan derivative 3-methyl-4-[{2-(2-phenylacetyl)hydrazono}methyl]-furoxan <strong>3f</strong> showed greater anti-inflammatory activity comparable to standard drug ibuprofen. The compound also showed reduced ulcerogenicity and high nitric oxide releasing properties. |
|
| Date |
2018-07-23T06:48:39Z
2018-07-23T06:48:39Z 2018-07 |
|
| Type |
Article
|
|
| Identifier |
0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/44750 |
|
| Language |
en_US
|
|
| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
|
|
| Publisher |
NISCAIR-CSIR, India
|
|
| Source |
IJC-B Vol.57B(07) [July 2018]
|
|