Synthesis of 4-(2-(substituted phenyl)diazenyl)-1-phenylpyrazolidine-3,5-dione catalyzed by <img src='http://www.niscair.res.in/jinfo/small.gif' border=0>-proline and their biological activity
IR@NISCAIR: CSIR-NISCAIR, New Delhi - ONLINE PERIODICALS REPOSITORY (NOPR)
View Archive Info| Field | Value | |
| Title |
Synthesis of 4-(2-(substituted phenyl)diazenyl)-1-phenylpyrazolidine-3,5-dione catalyzed by <img src='http://www.niscair.res.in/jinfo/small.gif' border=0>-proline and their biological activity
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| Creator |
Bhirud, Jayashri D
Mahulikar, Pramod P Narkhede, Hemant P |
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| Subject |
Pyrazolidine
Diethylmalonate <img src='http://www.niscair.res.in/jinfo/small.gif' border=0>-proline Well diffusion method |
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| Description |
1208-1212
<img src='http://www.niscair.res.in/jinfo/small.gif' border=0>-Proline as an efficient and eco-friendly catalyst has been employed for the synthesis of 4-(2-(substitutedphenyl)-diazenyl)-1-phenylpyrazolidine-3,5-dione from diethyl 2-(2-(substitutedphenyl)-hydrazono)malonate and phenyl hydrazine. This protocol exhibits advantages like high catalytic efficiency, shorter reaction time and easy isolation of products. The synthesized compounds have been structurally characterized on the basis of IR, <sup>1</sup>H and <sup>13</sup>C NMR, mass spectroscopy and elemental analyses. All of the newly isolated compounds have been tested for their antibacterial activities. The antibacterial screening using the agar well diffusion method reveals that the fluro derivative <strong>3e</strong> is the most active one. |
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| Date |
2018-09-13T05:52:51Z
2018-09-13T05:52:51Z 2018-09 |
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| Type |
Article
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| Identifier |
0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/45042 |
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| Language |
en_US
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| Rights |
<img src='http://nopr.niscair.res.in/image/cc-license-sml.png'> <a href='http://creativecommons.org/licenses/by-nc-nd/2.5/in' target='_blank'>CC Attribution-Noncommercial-No Derivative Works 2.5 India</a>
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| Publisher |
NISCAIR-CSIR, India
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| Source |
IJC-B Vol.57B(09) [September 2018]
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